Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain
Identifieur interne : 000E60 ( Main/Exploration ); précédent : 000E59; suivant : 000E61Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain
Auteurs : John Steel ; Anice C. Lowen ; Taia T. Wang ; Mark Yondola ; Qinshan Gao ; Kester Haye ; Adolfo García-Sastre ; Peter PaleseSource :
- mBio [ 2150-7511 ] ; 2010.
Abstract
Although highly effective in the general population when well matched to circulating influenza virus strains, current influenza vaccines are limited in their utility due to the narrow breadth of protection they provide. The strain specificity of vaccines presently in use mirrors the exquisite specificity of the neutralizing antibodies that they induce, that is, antibodies which bind to the highly variable globular head domain of hemagglutinin (HA). Herein, we describe the construction of a novel immunogen comprising the conserved influenza HA stalk domain and lacking the globular head. Vaccination of mice with this headless HA construct elicited immune sera with broader reactivity than those obtained from mice immunized with a full-length HA. Furthermore, the headless HA vaccine provided full protection against death and partial protection against disease following lethal viral challenge. Our results suggest that the response induced by headless HA vaccines is sufficiently potent to warrant their further development toward a universal influenza virus vaccine.
Url:
DOI: 10.1128/mBio.00018-10
PubMed: 20689752
PubMed Central: 2912658
Affiliations:
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Lowen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wang, Taia T" sort="Wang, Taia T" uniqKey="Wang T" first="Taia T." last="Wang">Taia T. Wang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Yondola, Mark" sort="Yondola, Mark" uniqKey="Yondola M" first="Mark" last="Yondola">Mark Yondola</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Gao, Qinshan" sort="Gao, Qinshan" uniqKey="Gao Q" first="Qinshan" last="Gao">Qinshan Gao</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Haye, Kester" sort="Haye, Kester" uniqKey="Haye K" first="Kester" last="Haye">Kester Haye</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Palese, Peter" sort="Palese, Peter" uniqKey="Palese P" first="Peter" last="Palese">Peter Palese</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author></analytic><series><title level="j">mBio</title><idno type="eISSN">2150-7511</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><p>Although highly effective in the general population when well matched to circulating influenza virus strains, current influenza vaccines are limited in their utility due to the narrow breadth of protection they provide. The strain specificity of vaccines presently in use mirrors the exquisite specificity of the neutralizing antibodies that they induce, that is, antibodies which bind to the highly variable globular head domain of hemagglutinin (HA). Herein, we describe the construction of a novel immunogen comprising the conserved influenza HA stalk domain and lacking the globular head. Vaccination of mice with this headless HA construct elicited immune sera with broader reactivity than those obtained from mice immunized with a full-length HA. Furthermore, the headless HA vaccine provided full protection against death and partial protection against disease following lethal viral challenge. Our results suggest that the response induced by headless HA vaccines is sufficiently potent to warrant their further development toward a universal influenza virus vaccine.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fox, J P" uniqKey="Fox J">J. P. Fox</name></author><author><name sortKey="Cooney, M K" uniqKey="Cooney M">M. K. Cooney</name></author><author><name sortKey="Hall, C E" uniqKey="Hall C">C. E. Hall</name></author><author><name sortKey="Foy, H M" uniqKey="Foy H">H. M. Foy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glezen, W P" uniqKey="Glezen W">W. P. Glezen</name></author><author><name sortKey="Couch, R B" uniqKey="Couch R">R. B. Couch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belshe, R B" uniqKey="Belshe R">R. B. Belshe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thompson, W W" uniqKey="Thompson W">W. W. Thompson</name></author><author><name sortKey="Shay, D K" uniqKey="Shay D">D. K. Shay</name></author><author><name sortKey="Weintraub, E" uniqKey="Weintraub E">E. Weintraub</name></author><author><name sortKey="Brammer, L" uniqKey="Brammer L">L. Brammer</name></author><author><name sortKey="Cox, N" uniqKey="Cox N">N. Cox</name></author><author><name sortKey="Anderson, L J" uniqKey="Anderson L">L. J. Anderson</name></author><author><name sortKey="Fukuda, K" uniqKey="Fukuda K">K. Fukuda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, N P" uniqKey="Johnson N">N. P. Johnson</name></author><author><name sortKey="Mueller, J" uniqKey="Mueller J">J. Mueller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wright, P F" uniqKey="Wright P">P. F. Wright</name></author><author><name sortKey="Neumann, G" uniqKey="Neumann G">G. Neumann</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y. Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bridges, C B" uniqKey="Bridges C">C. B. Bridges</name></author><author><name sortKey="Thompson, W W" uniqKey="Thompson W">W. W. Thompson</name></author><author><name sortKey="Meltzer, M I" uniqKey="Meltzer M">M. I. Meltzer</name></author><author><name sortKey="Reeve, G R" uniqKey="Reeve G">G. R. Reeve</name></author><author><name sortKey="Talamonti, W J" uniqKey="Talamonti W">W. J. Talamonti</name></author><author><name sortKey="Cox, N J" uniqKey="Cox N">N. J. Cox</name></author><author><name sortKey="Lilac, H A" uniqKey="Lilac H">H. A. Lilac</name></author><author><name sortKey="Hall, H" uniqKey="Hall H">H. Hall</name></author><author><name sortKey="Klimov, A" uniqKey="Klimov A">A. Klimov</name></author><author><name sortKey="Fukuda, K" uniqKey="Fukuda K">K. Fukuda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Jong, J C" uniqKey="De Jong J">J. C. de Jong</name></author><author><name sortKey="Beyer, W E" uniqKey="Beyer W">W. E. Beyer</name></author><author><name sortKey="Palache, A M" uniqKey="Palache A">A. M. Palache</name></author><author><name sortKey="Rimmelzwaan, G F" uniqKey="Rimmelzwaan G">G. F. Rimmelzwaan</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A. D. Osterhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graves, P N" uniqKey="Graves P">P. N. Graves</name></author><author><name sortKey="Schulman, J L" uniqKey="Schulman J">J. L. Schulman</name></author><author><name sortKey="Young, J F" uniqKey="Young J">J. F. Young</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krystal, M" uniqKey="Krystal M">M. Krystal</name></author><author><name sortKey="Elliott, R M" uniqKey="Elliott R">R. M. Elliott</name></author><author><name sortKey="Benz, E W" uniqKey="Benz E">E. W. Benz</name></author><author><name sortKey="Young, J F" uniqKey="Young J">J. F. Young</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ekiert, D C" uniqKey="Ekiert D">D. C. Ekiert</name></author><author><name sortKey="Bhabha, G" uniqKey="Bhabha G">G. Bhabha</name></author><author><name sortKey="Elsliger, M A" uniqKey="Elsliger M">M. A. Elsliger</name></author><author><name sortKey="Friesen, R H" uniqKey="Friesen R">R. H. Friesen</name></author><author><name sortKey="Jongeneelen, M" uniqKey="Jongeneelen M">M. Jongeneelen</name></author><author><name sortKey="Throsby, M" uniqKey="Throsby M">M. Throsby</name></author><author><name sortKey="Goudsmit, J" uniqKey="Goudsmit J">J. Goudsmit</name></author><author><name sortKey="Wilson, I A" uniqKey="Wilson I">I. A. Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kashyap, A K" uniqKey="Kashyap A">A. K. Kashyap</name></author><author><name sortKey="Steel, J" uniqKey="Steel J">J. Steel</name></author><author><name sortKey="Oner, A F" uniqKey="Oner A">A. F. Oner</name></author><author><name sortKey="Dillon, M A" uniqKey="Dillon M">M. A. Dillon</name></author><author><name sortKey="Swale, R E" uniqKey="Swale R">R. E. Swale</name></author><author><name sortKey="Wall, K M" uniqKey="Wall K">K. M. Wall</name></author><author><name sortKey="Perry, K J" uniqKey="Perry K">K. J. Perry</name></author><author><name sortKey="Faynboym, A" uniqKey="Faynboym A">A. Faynboym</name></author><author><name sortKey="Ilhan, M" uniqKey="Ilhan M">M. Ilhan</name></author><author><name sortKey="Horowitz, M" uniqKey="Horowitz M">M. Horowitz</name></author><author><name sortKey="Horowitz, L" uniqKey="Horowitz L">L. Horowitz</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author><author><name sortKey="Bhatt, R R" uniqKey="Bhatt R">R. R. Bhatt</name></author><author><name sortKey="Lerner, R A" uniqKey="Lerner R">R. A. Lerner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okuno, Y" uniqKey="Okuno Y">Y. Okuno</name></author><author><name sortKey="Isegawa, Y" uniqKey="Isegawa Y">Y. Isegawa</name></author><author><name sortKey="Sasao, F" uniqKey="Sasao F">F. Sasao</name></author><author><name sortKey="Ueda, S" uniqKey="Ueda S">S. Ueda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sui, J" uniqKey="Sui J">J. Sui</name></author><author><name sortKey="Hwang, W C" uniqKey="Hwang W">W. C. Hwang</name></author><author><name sortKey="Perez, S" uniqKey="Perez S">S. Perez</name></author><author><name sortKey="Wei, G" uniqKey="Wei G">G. Wei</name></author><author><name sortKey="Aird, D" uniqKey="Aird D">D. Aird</name></author><author><name sortKey="Chen, L M" uniqKey="Chen L">L. M. Chen</name></author><author><name sortKey="Santelli, E" uniqKey="Santelli E">E. Santelli</name></author><author><name sortKey="Stec, B" uniqKey="Stec B">B. Stec</name></author><author><name sortKey="Cadwell, G" uniqKey="Cadwell G">G. Cadwell</name></author><author><name sortKey="Ali, M" uniqKey="Ali M">M. Ali</name></author><author><name sortKey="Wan, H" uniqKey="Wan H">H. Wan</name></author><author><name sortKey="Murakami, A" uniqKey="Murakami A">A. Murakami</name></author><author><name sortKey="Yammanuru, A" uniqKey="Yammanuru A">A. Yammanuru</name></author><author><name sortKey="Han, T" uniqKey="Han T">T. Han</name></author><author><name sortKey="Cox, N J" uniqKey="Cox N">N. J. Cox</name></author><author><name sortKey="Bankston, L A" uniqKey="Bankston L">L. A. Bankston</name></author><author><name sortKey="Donis, R O" uniqKey="Donis R">R. O. Donis</name></author><author><name sortKey="Liddington, R C" uniqKey="Liddington R">R. C. Liddington</name></author><author><name sortKey="Marasco, W A" uniqKey="Marasco W">W. A. Marasco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stevens, J" uniqKey="Stevens J">J. Stevens</name></author><author><name sortKey="Corper, A L" uniqKey="Corper A">A. L. Corper</name></author><author><name sortKey="Basler, C F" uniqKey="Basler C">C. F. Basler</name></author><author><name sortKey="Taubenberger, J K" uniqKey="Taubenberger J">J. K. Taubenberger</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author><author><name sortKey="Wilson, I A" uniqKey="Wilson I">I. A. Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author><author><name sortKey="Shaw, M L" uniqKey="Shaw M">M. L. Shaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, T T" uniqKey="Wang T">T. T. Wang</name></author><author><name sortKey="Tan, G S" uniqKey="Tan G">G. S. Tan</name></author><author><name sortKey="Hai, R" uniqKey="Hai R">R. Hai</name></author><author><name sortKey="Pica, N" uniqKey="Pica N">N. Pica</name></author><author><name sortKey="Petersen, E" uniqKey="Petersen E">E. Petersen</name></author><author><name sortKey="Moran, T" uniqKey="Moran T">T. Moran</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hermida Matsumoto, L" uniqKey="Hermida Matsumoto L">L. Hermida-Matsumoto</name></author><author><name sortKey="Resh, M D" uniqKey="Resh M">M. D. Resh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miyazaki, J" uniqKey="Miyazaki J">J. Miyazaki</name></author><author><name sortKey="Takaki, S" uniqKey="Takaki S">S. Takaki</name></author><author><name sortKey="Araki, K" uniqKey="Araki K">K. Araki</name></author><author><name sortKey="Tashiro, F" uniqKey="Tashiro F">F. Tashiro</name></author><author><name sortKey="Tominaga, A" uniqKey="Tominaga A">A. Tominaga</name></author><author><name sortKey="Takatsu, K" uniqKey="Takatsu K">K. Takatsu</name></author><author><name sortKey="Yamamura, K" uniqKey="Yamamura K">K. Yamamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quinlivan, M" uniqKey="Quinlivan M">M. Quinlivan</name></author><author><name sortKey="Zamarin, D" uniqKey="Zamarin D">D. Zamarin</name></author><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A. Garcia-Sastre</name></author><author><name sortKey="Cullinane, A" uniqKey="Cullinane A">A. Cullinane</name></author><author><name sortKey="Chambers, T" uniqKey="Chambers T">T. Chambers</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fodor, E" uniqKey="Fodor E">E. Fodor</name></author><author><name sortKey="Devenish, L" uniqKey="Devenish L">L. Devenish</name></author><author><name sortKey="Engelhardt, O G" uniqKey="Engelhardt O">O. G. Engelhardt</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author><author><name sortKey="Brownlee, G G" uniqKey="Brownlee G">G. G. Brownlee</name></author><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A. Garcia-Sastre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, S" uniqKey="Wang S">S. Wang</name></author><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q. Liu</name></author><author><name sortKey="Pu, J" uniqKey="Pu J">J. Pu</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Keleta, L" uniqKey="Keleta L">L. Keleta</name></author><author><name sortKey="Hu, Y W" uniqKey="Hu Y">Y. W. Hu</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J. Liu</name></author><author><name sortKey="Brown, E G" uniqKey="Brown E">E. G. Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steel, J" uniqKey="Steel J">J. Steel</name></author><author><name sortKey="Burmakina, S V" uniqKey="Burmakina S">S. V. Burmakina</name></author><author><name sortKey="Thomas, C" uniqKey="Thomas C">C. Thomas</name></author><author><name sortKey="Spackman, E" uniqKey="Spackman E">E. Spackman</name></author><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A. Garcia-Sastre</name></author><author><name sortKey="Swayne, D E" uniqKey="Swayne D">D. E. Swayne</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author><author><name sortKey="Schulman, J L" uniqKey="Schulman J">J. L. Schulman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luxembourg, A" uniqKey="Luxembourg A">A. Luxembourg</name></author><author><name sortKey="Evans, C F" uniqKey="Evans C">C. F. Evans</name></author><author><name sortKey="Hannaman, D" uniqKey="Hannaman D">D. Hannaman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luxembourg, A" uniqKey="Luxembourg A">A. Luxembourg</name></author><author><name sortKey="Hannaman, D" uniqKey="Hannaman D">D. Hannaman</name></author><author><name sortKey="Nolan, E" uniqKey="Nolan E">E. Nolan</name></author><author><name sortKey="Ellefsen, B" uniqKey="Ellefsen B">B. Ellefsen</name></author><author><name sortKey="Nakamura, G" uniqKey="Nakamura G">G. Nakamura</name></author><author><name sortKey="Chau, L" uniqKey="Chau L">L. Chau</name></author><author><name sortKey="Tellez, O" uniqKey="Tellez O">O. Tellez</name></author><author><name sortKey="Little, S" uniqKey="Little S">S. Little</name></author><author><name sortKey="Bernard, R" uniqKey="Bernard R">R. Bernard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lowen, A C" uniqKey="Lowen A">A. C. Lowen</name></author><author><name sortKey="Steel, J" uniqKey="Steel J">J. Steel</name></author><author><name sortKey="Mubareka, S" uniqKey="Mubareka S">S. Mubareka</name></author><author><name sortKey="Carnero, E" uniqKey="Carnero E">E. Carnero</name></author><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A. Garcia-Sastre</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sagawa, H" uniqKey="Sagawa H">H. Sagawa</name></author><author><name sortKey="Ohshima, A" uniqKey="Ohshima A">A. Ohshima</name></author><author><name sortKey="Kato, I" uniqKey="Kato I">I. Kato</name></author><author><name sortKey="Okuno, Y" uniqKey="Okuno Y">Y. Okuno</name></author><author><name sortKey="Isegawa, Y" uniqKey="Isegawa Y">Y. Isegawa</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Gao, Qinshan" sort="Gao, Qinshan" uniqKey="Gao Q" first="Qinshan" last="Gao">Qinshan Gao</name><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name><name sortKey="Haye, Kester" sort="Haye, Kester" uniqKey="Haye K" first="Kester" last="Haye">Kester Haye</name><name sortKey="Lowen, Anice C" sort="Lowen, Anice C" uniqKey="Lowen A" first="Anice C." last="Lowen">Anice C. Lowen</name><name sortKey="Palese, Peter" sort="Palese, Peter" uniqKey="Palese P" first="Peter" last="Palese">Peter Palese</name><name sortKey="Steel, John" sort="Steel, John" uniqKey="Steel J" first="John" last="Steel">John Steel</name><name sortKey="Wang, Taia T" sort="Wang, Taia T" uniqKey="Wang T" first="Taia T." last="Wang">Taia T. Wang</name><name sortKey="Yondola, Mark" sort="Yondola, Mark" uniqKey="Yondola M" first="Mark" last="Yondola">Mark Yondola</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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